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Anticancer Res. 1998 Jul-Aug;18(4B):2901-4.

DNA content of parathyroid tumors.

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  • 1Ist Institute Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Budapest, Hungary.

Abstract

BACKGROUND:

The significance of DNA ploidy in indicating the benign or malignant character of parathyroid and other endocrin tumors is controversial.

MATERIALS AND METHODS:

DNA content of paraffin embedded parathyroid samples from 25 patients was measured with flow cytometry.

RESULTS:

The DNA index (DI) was 1.0 in all nonneoplastic samples as well as in 50% of adenomas (10/20) and in one carcinoma (1/2). The remaining 45% of the adenoma cases (9/20) and the other carcinoma showed doubled DNA content (DI = 1.9-2.0). The increased DI did not correlate with either clinical data (sex, age, tumor size, preoperative serum Ca++ or parathormone, primary or secondary hyperparathyroidism) or morphology.

CONCLUSIONS:

These results indicate that the DI has no value in deciding the benign or malignant character of a given sample. However, the prognostic value of tetraploidization (the potentially increased risk for malignancy) could not be ruled out.

PMID:
9713484
[PubMed - indexed for MEDLINE]
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