Prevention of allogeneic fetal rejection by trypto...[Science. 1998]

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1: Science. 1998 Aug 21;281(5380):1191-3. Links

Comment in:: Science. 1998 Aug 21;281(5380):1122-4.

Prevention of allogeneic fetal rejection by tryptophan catabolism.

Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B, Brown C, Mellor AL.

Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA.

In 1953 Medawar pointed out that survival of the genetically disparate (allogeneic) mammalian conceptus contradicts the laws of tissue transplantation. Rapid T cell-induced rejection of all allogeneic concepti occurred when pregnant mice were treated with a pharmacologic inhibitor of indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme expressed by trophoblasts and macrophages. Thus, by catabolizing tryptophan, the mammalian conceptus suppresses T cell activity and defends itself against rejection.

PMID: 9712583 [PubMed - indexed for MEDLINE]

Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy.
Nat Immunol. 2001 Jan; 2(1):64-8.

[Nat Immunol. 2001]
How embryos may avoid immune attack.
Science. 1998 Aug 21; 281(5380):1122-4.

[Science. 1998]
Human placental indoleamine 2,3-dioxygenase: cellular localization and characterization of an enzyme preventing fetal rejection.
Biochim Biophys Acta. 2000 Jan 3; 1500(1):119-24.

[Biochim Biophys Acta. 2000]
ReviewIndoleamine 2,3-dioxygenase, immunosuppression and pregnancy.
J Reprod Immunol. 2002 Oct-Nov; 57(1-2):143-50.

[J Reprod Immunol. 2002]
ReviewTryptophan catabolism and T-cell tolerance: immunosuppression by starvation?
Immunol Today. 1999 Oct; 20(10):469-73.

[Immunol Today. 1999]
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