J Neurosci Res. 1998 Aug 15;53(4):490-3.

Amantadine increases aromatic L-amino acid decarboxylase mRNA in PC12 cells.

Source

Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada. lixinm@sask.usask.ca

Abstract

Amantadine is an antiviral agent that was unexpectedly found to cause symptomatic improvement in patients with Parkinsonism, although its mechanism of action remains to be elucidated. Aromatic L-amino acid decarboxylase (AADC) is a regulated enzyme that catalyzes the decarboxylation of 3,4-dihydroxyphenylalanine (L-Dopa). It may be especially important during L-Dopa therapy in Parkinsonism, during which it may be rate-limiting for the production of dopamine. This study reports the effects of amantadine on the gene expression of AADC in PC12 cells. It shows that amantadine induces AADC gene expression at concentrations of 10 and 100 microM after 24 hr of incubation. The results suggest that the stimulation of AADC mRNA by amantadine may be one of its effects on dopamine metabolism that may have relevance for potentiation of L-Dopa therapy in Parkinsonism.

PMID:: 9710269; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

AMANTADINE - HSDB

Supplemental Content

Save items

Related citations in PubMed

L-deprenyl induces aromatic L-amino acid decarboxylase (AADC) mRNA in the rat substantia nigra and ventral tegmentum. An in situ hybridization study. [Mol Chem Neuropathol. 1998]
L-deprenyl induces aromatic L-amino acid decarboxylase (AADC) mRNA in the rat substantia nigra and ventral tegmentum. An in situ hybridization study.
Li XM, Juorio AV, Qi J, Boulton AA. Mol Chem Neuropathol. 1998 Aug-Dec; 35(1-3):149-55.
Does phenylethylamine have a role in schizophrenia?: LSD and PCP up-regulate aromatic L-amino acid decarboxylase mRNA levels. [Brain Res Mol Brain Res. 1997]
Does phenylethylamine have a role in schizophrenia?: LSD and PCP up-regulate aromatic L-amino acid decarboxylase mRNA levels.
Buckland PR, Marshall R, Watkins P, McGuffin P. Brain Res Mol Brain Res. 1997 Oct 3; 49(1-2):266-70.
NSD-1015 alters the gene expression of aromatic L-amino acid decarboxylase in rat PC12 pheochromocytoma cells. [Neurochem Res. 1993]
NSD-1015 alters the gene expression of aromatic L-amino acid decarboxylase in rat PC12 pheochromocytoma cells.
Li XM, Juorio AV, Boulton AA. Neurochem Res. 1993 Aug; 18(8):915-9.
Review Aromatic L-amino acid decarboxylase: a neglected and misunderstood enzyme. [Neurochem Res. 1996]
Review Aromatic L-amino acid decarboxylase: a neglected and misunderstood enzyme.
Berry MD, Juorio AV, Li XM, Boulton AA. Neurochem Res. 1996 Sep; 21(9):1075-87.
Review [Molecular genetics of aromatic L-amino acid decarboxylase]. [Yakubutsu Seishin Kodo. 1993]
Review [Molecular genetics of aromatic L-amino acid decarboxylase].
Ichinose H, Nagatsu T. Yakubutsu Seishin Kodo. 1993 Aug; 13(4):251-6.

See reviews... See all...

Cited by 1 PubMed Central article

Possible new mechanism for the antiparkinsonian effect of amantadine. [J Psychiatry Neurosci. 1999]
Possible new mechanism for the antiparkinsonian effect of amantadine.
Bennett VL, Juorio AV, Li XM. J Psychiatry Neurosci. 1999 Jan; 24(1):52-3.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Amantadine increases aromatic L-amino acid decarboxylase mRNA in PC12 cells.
Amantadine increases aromatic L-amino acid decarboxylase mRNA in PC12 cells.
J Neurosci Res. 1998 Aug 15 ;53(4):490-3.

PubMed
Deleterious missense mutations and silent polymorphism in the human 17beta-hydro...
Deleterious missense mutations and silent polymorphism in the human 17beta-hydroxysteroid dehydrogenase 3 gene (HSD17B3).
J Clin Endocrinol Metab. 1998 Aug ;83(8):2855-60.

PubMed
Daily oral magnesium supplementation suppresses bone turnover in young adult mal...
Daily oral magnesium supplementation suppresses bone turnover in young adult males.
J Clin Endocrinol Metab. 1998 Aug ;83(8):2742-8.

PubMed
Clinical and radiological survey of the incidence of osteoarthrosis among obese ...
Clinical and radiological survey of the incidence of osteoarthrosis among obese patients.
Ann Rheum Dis. 1976 Aug ;35(4):349-53.

PubMed
High-resolution computed tomography for the diagnosis of community-acquired pneu...
High-resolution computed tomography for the diagnosis of community-acquired pneumonia.
Clin Infect Dis. 1998 Aug ;27(2):358-63.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: