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J Pediatr. 1998 Aug;133(2):286-9.

Macroenzyme investigation and monitoring in children with persistent increase of aspartate aminotransferase of unexplained origin.

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  • 1Department of Biochemistry and Medical Biotechnology, Medical School, University of Naples Federico II, Italy.


Ten children with asymptomatic persistent cryptogenic increased serum levels of aspartate aminotransferase (AST) were screened for detection and monitoring of AST macroenzyme (macroAST). MacroAST was found in 4 patients; their serum AST levels were significantly higher than in those without biochemical evidence of macroAST (mean +/- SD: 515 +/- 433 and 78 +/- 16 IU/L, respectively; P = .0095). MacroAST was a persistent, benign phenomenon and was probably not congenital.

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