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Neuropediatrics. 1998 Jun;29(3):113-9.

Microlissencephaly: a heterogeneous malformation of cortical development.

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  • 1Faculté de Médicine Xavier-Bichat (Université de Paris VII), Hôpital Robert-Debré, France.


We report the neonatal courses, early postnatal development, and neuroimaging findings of 17 patients with marked microcephaly and simplified cerebral gyral patterns, a condition that we call microlissencephaly. Retrospective analyses of the clinicoradiologic features of these patients allowed segregation of the patients into 5 distinct groups with varying outcomes. The apparent discreteness of these groups suggests multiple etiologies of this malformation, although there appears to be a strong genetic component with probable autosomal recessive inheritance. Utilizing the neonatal course and neuroradiologic features of these infants allows classification of specific subsets, which may be useful to predict outcome.

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