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Curr Biol. 1998 Jul 16;8(15):R535-8.

Lymphocyte signalling: a coordinating role for Vav?

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  • 1Lymphocyte Activation Laboratory, Imperial Cancer Research Fund, London, UK.

Abstract

Vav1 is a guanine nucleotide exchange factor that selectively activates the Rac1 GTPase and is expressed specifically in haematopoietic cells. Recent work has revealed how Vav1 integrates signals from lymphocyte antigen receptors and costimulatory receptors to control immune function.

PMID:
9705925
[PubMed - indexed for MEDLINE]
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