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1: Neuroepidemiology. 1998;17(5):225-32.Click here to read Links

Gene-environment interaction in Alzheimer's disease: a potential role for cholesterol.

Chandra V, Pandav R.

Centre for Ageing Research, India, New Delhi, India. VIJAY@CARI.ERNET.IN

Alzheimer's disease is probably a complex disease caused by an interaction of multiple environmental and genetic factors. Genetic defects include 'causative' genes which are rare and a 'susceptibility' gene (sigma4 allele of apolipoprotein E) which is more common in cases. Recent research suggests that environmental factors may interact with a genetic predisposition to modify the risk of Alzheimer's disease. An interaction between serum cholesterol levels and sigma4 genotype is proposed. The evidence for this gene-environment interaction is discussed.

PMID: 9705582 [PubMed - indexed for MEDLINE]