Am J Psychiatry. 1976 Oct;133(10):1177-80.

A dopaminergic mechanism in mania.

Abstract

The authors present a case study that explores the relationship of dopamine function and manic illness through the use of two drugs with relatively specific effects in stimulating and blocking dopamine receptors--piribedil (ET--495) and pimozide, respectively. Piribedil, as well as d-amphetamine, was associated with manic episodes, while pimozide had an antimanic effect. These observations suggest that dopaminergic mechanisms may be involved in the mediation of manic episodes in at least some patients.

PMID:: 970489; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Molecular Biology Databases

Supplemental Content

Icon for Silverchair Information Systems

Save items

Related citations in PubMed

Effects of a dopamine agonist piribedil in depressed patients: relationship of pretreatment homovanillic acid to antidepressant response. [Arch Gen Psychiatry. 1978]
Effects of a dopamine agonist piribedil in depressed patients: relationship of pretreatment homovanillic acid to antidepressant response.
Post RM, Gerner RH, Carman JS, Gillin JC, Jimerson DC, Goodwin FK, Bunney WE Jr. Arch Gen Psychiatry. 1978 May; 35(5):609-15.
Review [Antipsychotics in bipolar disorders]. [Encephale. 2004]
Review [Antipsychotics in bipolar disorders].
Vacheron-Trystram MN, Braitman A, Cheref S, Auffray L. Encephale. 2004 Sep-Oct; 30(5):417-24.
Dopamine and mania: behavioral and biochemical effects of the dopamine receptor blocker pimozide. [Psychopharmacology (Berl). 1980]
Dopamine and mania: behavioral and biochemical effects of the dopamine receptor blocker pimozide.
Post RM, Jimerson DC, Bunney WE Jr, Goodwin FK. Psychopharmacology (Berl). 1980; 67(3):297-305.
The effect of lithium treatment on manic symptoms and levels of monoamine metabolites in cerebrospinal fluid of manic depressive patients. [Psychopharmacologia. 1975]
The effect of lithium treatment on manic symptoms and levels of monoamine metabolites in cerebrospinal fluid of manic depressive patients.
Fyrö B, Petterson U, Sedvall G. Psychopharmacologia. 1975 Oct 14; 44(1):99-103.
Review Pharmacotherapy of depression--a critical review. [Psychosomatics. 1975]
Review Pharmacotherapy of depression--a critical review.
Ban TA. Psychosomatics. 1975; 16(1):17-20.

See reviews... See all...

Cited by 5 PubMed Central articles

Tricyclic anti-depressant induced mania. [Indian J Psychiatry. 1980]
Tricyclic anti-depressant induced mania.
Sethi BB, Prakash R, Sharma M, Sahai J. Indian J Psychiatry. 1980 Oct; 22(4):378-83.
Neurochemical and psychoanalytical approaches to mania. [Proc R Soc Med. 1977]
Neurochemical and psychoanalytical approaches to mania.
Cookson JC, Silverstone T. Proc R Soc Med. 1977; 70(Suppl 10):20-5.
A test of the effects of acute sleep deprivation on general and specific self-reported anxiety and depressive symptoms: an experimental extension. [J Behav Ther Exp Psychiatry. 2...]
A test of the effects of acute sleep deprivation on general and specific self-reported anxiety and depressive symptoms: an experimental extension.
Babson KA, Trainor CD, Feldner MT, Blumenthal H. J Behav Ther Exp Psychiatry. 2010 Sep; 41(3):297-303. Epub 2010 Feb 23.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

A dopaminergic mechanism in mania.
A dopaminergic mechanism in mania.
Am J Psychiatry. 1976 Oct ;133(10):1177-80.

PubMed
Age-dependent decline of dopamine D1 receptors in human brain: a PET study.
Age-dependent decline of dopamine D1 receptors in human brain: a PET study.
Synapse. 1998 Sep ;30(1):56-61.

PubMed
Impact of a district branch Task Force on women.
Impact of a district branch Task Force on women.
Am J Psychiatry. 1976 Oct ;133(10):1159-64.

PubMed
Serotonergic function in social phobia: comparison to normal control and obsessi...
Serotonergic function in social phobia: comparison to normal control and obsessive-compulsive disorder subjects.
Psychiatry Res. 1998 Jul 13 ;79(3):213-7.

PubMed
Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent l...
Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program.
J Clin Oncol. 1998 Aug ;16(8):2825-33.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

A dopaminergic mechanism in mania.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 5 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information