EBV specific CTL: a model for immune therapy. [Vox Sang. 1998]

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1: Vox Sang. 1998;74 Suppl 2:497-8. Links

EBV specific CTL: a model for immune therapy.

Rooney CM, Heslop HE, Brenner MK.

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA. cmrooney@msmail.his.tch.tmc.edu

We have been generating Epstein-Barr virus specific cytotoxic T cells for patients at high risk of developing EBV driven lymphoma. To discover the fate of the cells in vivo, we first marked them genetically, using a retroviral vector. Our results in 51 patients show that the approach is safe, that the CTL persist for several years and that they are able to mediate anti-viral and anti-tumor effects. We are now studying other virally-linked malignancies to discover whether a similar approach will be of therapeutic value.

PMID: 9704488 [PubMed - indexed for MEDLINE]

Epstein-Barr virus (EBV) load in bone marrow transplant recipients at risk to develop posttransplant lymphoproliferative disease: prophylactic infusion of EBV-specific cytotoxic T cells.
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[Blood. 2000]
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Blood Rev. 2004 Sep; 18(3):193-209.

[Blood Rev. 2004]
ReviewAdoptive immunotherapy for Epstein-Barr virus-associated lymphoproliferative disorders complicating marrow allografts.
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[Springer Semin Immunopathol. 1998]
An Epstein-Barr virus deletion mutant associated with fatal lymphoproliferative disease unresponsive to therapy with virus-specific CTLs.
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[Blood. 2001]
Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for the prevention and treatment of EBV-associated post-transplant lymphomas.
Recent Results Cancer Res. 2002; 159:123-33.

[Recent Results Cancer Res. 2002]
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