Send to:

Choose Destination
See comment in PubMed Commons below
Transplantation. 1998 Jul 27;66(2):268-71.

Uricosuric effect of the angiotensin II receptor antagonist losartan in heart transplant recipients.

Author information

  • 1Policlinique M├ędicale Universitaire and Division of Hypertension, CHUV, Lausanne, Switzerland.



The angiotensin II receptor antagonist losartan is an effective antihypertensive agent with unique uricosuric properties. This study evaluates the uricosuric effects of losartan in 10 hypertensive heart transplant patients with hyperuricemia.


The patients were randomized to receive losartan 50 mg once daily and enalapril 20 mg once daily for 4 weeks according to a double-blind crossover design. Office blood pressure, plasma uric acid levels, and urinary uric acid excretion were monitored throughout the study.


Plasma uric acid levels decreased significantly after 4 weeks of treatment with losartan (P<0.05) but not with enalapril. On day 1 and after 1 month of treatment, a significant increase in uric acid excretion was observed only with losartan. Significant decreases in office systolic and diastolic blood pressures were obtained with enalapril but not with losartan.


Losartan effectively lowers plasma uric acid levels in hyperuricemic heart transplant patients.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk