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J Cell Biol. 1998 Aug 10;142(3):787-801.

Mitotic centromere-associated kinesin is important for anaphase chromosome segregation.

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  • 1Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98195, USA.


Mitotic centromere-associated kinesin (MCAK) is recruited to the centromere at prophase and remains centromere associated until after telophase. MCAK is a homodimer that is encoded by a single gene and has no associated subunits. A motorless version of MCAK that binds centromeres but not microtubules disrupts chromosome segregation during anaphase. Antisense-induced depletion of MCAK results in the same defect. MCAK overexpression induces centromere-independent bundling and eventual loss of spindle microtubule polymer suggesting that centromere-associated bundling and/or depolymerization activity is required for anaphase. Live cell imaging indicates that MCAK may be required to coordinate the onset of sister centromere separation.

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