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Pac Symp Biocomput. 1998:240-51.

A discrimination study of human core-promoters.

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  • Cold Spring Harbor Laboratory, NY 11724, USA.

Abstract

A core-promoter, approximately from -60 bp upstream to +40 bp downstream of a RNA polymerase (RNAP) II transcription start site (TSS), binds to the preinitiation complex (PIC) and determine the position of TSS. Using position-specific k-tuple feature variables, a quadratic discriminant analysis (QDA) method is shown to be very effective in identifying human core-promoters.

PMID:
9697186
[PubMed - indexed for MEDLINE]
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