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Ann Intern Med. 1998 Aug 1;129(3):241-4.

Primaquine prophylaxis against malaria in nonimmune Colombian soldiers: efficacy and toxicity. A randomized, double-blind, placebo-controlled trial.

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  • 1Universidad Militar Nueva Granada, Consorcio de Investigaciones Bioclinicas, Dirección de Sanidad Ejercito, Bogota, Columbia.

Abstract

BACKGROUND:

Primaquine had a prophylactic efficacy of 90% to 95% against infection with Plasmodium falciparum and P. vivax in Indonesian settlers.

OBJECTIVE:

To evaluate the efficacy of primaquine prophylaxis for protecting nonimmune persons from malaria.

DESIGN:

Randomized, double-blind, placebo-controlled field study.

SETTING:

A malaria-endemic area in Colombia.

PATIENTS:

176 healthy, young, nonimmune adult male soldiers.

INTERVENTION:

Primaquine, 30 mg/d, or matching placebo during 15 weeks of patrol in the endemic area and 1 week afterward.

MEASUREMENTS:

Symptomatic parasitemia was determined over the 16-week intervention period and for 3 weeks in base camp.

RESULTS:

Protective efficacy in the primaquine group (122 participants) was 89% (95% CI, 75% to 96%) against all types of malaria, 94% (CI, 78% to 99%) against P. falciparum malaria, and 85% (CI, 57% to 95%) against P. vivax malaria. Six primaquine recipients had mild to moderate gastrointestinal distress, and three had severe distress.

CONCLUSIONS:

For prophylaxis against P. falciparum malaria, primaquine has an efficacy and toxicity competitive with those of standard agents. A potential advantage of primaquine is that prophylaxis may be discontinued 1 week after the recipient has left the endemic area.

Comment in

PMID:
9696733
[PubMed - indexed for MEDLINE]
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