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Cancer Genet Cytogenet. 1998 Aug;105(1):39-42.

Occurrence of cancer in a cohort of 183 persons with constitutional chromosome 7 abnormalities.

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  • 1Department of Pediatrics, Aarhus University Hospital, Denmark.


Cytogenetic abnormalities in human malignancies frequently involve chromosome 7. The existence of several tumor suppressor genes on the long arm of chromosome 7 has been suggested in both epithelial and hematologic malignancies. From the Danish Cytogenetic Register, we identified 183 persons with constitutional abnormalities involving chromosome 7, including 16 patients with Williams syndrome. By linkage to the Danish Cancer Registry, we found five persons with cancer, including one thyroid carcinoma, three carcinomas of the digestive tract, and one malignant melanoma. There were no cases of leukemia. The overall risk of developing cancer was not increased.

[PubMed - indexed for MEDLINE]
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