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Curr Opin Neurobiol. 1998 Jun;8(3):330-4.

Regulation of ion channels by cAMP-dependent protein kinase and A-kinase anchoring proteins.

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  • 1Department of Pharmacology, University of Washington, Seattle 98195-7280, USA.


Subcellular targeting of the cAMP-dependent protein kinase is achieved, in part, through association with A-kinase anchoring proteins (AKAPs). Recent evidence suggests that specific AKAPs direct the kinase to submembrane sites to facilitate phosphorylation and modulation of a variety of ion channels. A new membrane-anchored AKAP targets cAMP-dependent protein kinase to calcium channels and enhances their regulation in multiple cell types.

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