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1: Mol Cell Endocrinol. 1998 Mar 16;138(1-2):199-203.Click here to read Links

Estrogen receptor-beta mRNA variants in human and murine tissues.

Lu B, Leygue E, Dotzlaw H, Murphy LJ, Murphy LC, Watson PH.

Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada.

Estrogen receptor (ER)-beta mRNA splice variants have been identified in human breast tumors as well as normal human and mouse ovarian, uterine and mammary tissues. In both species transcripts deleted in exons 5 or 6, or 5 + 6 have been characterized by RT-PCR followed by cloning and sequencing. In mouse tissues an ER-beta transcript containing 54 nucleotides inserted in frame between exons 5 and 6 was identified. Interestingly, no equivalent of the mouse inserted transcript was detected in any of the four human tissues analyzed.

PMID: 9685228 [PubMed - indexed for MEDLINE]

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