Format

Send to:

Choose Destination
See comment in PubMed Commons below
Clin Immunol Immunopathol. 1998 Jul;88(1):35-45.

A new murine model for mammalian wound repair and regeneration.

Author information

  • 1The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania, 19104, USA.

Abstract

Regeneration is generally considered to be a phenomenon restricted to amphibians in which amputated limbs reform and regrow. We have recently noted a strain of mouse, the MRL, which displays a remarkable capacity for cartilagenous wound closure and provides an example of a phenomenon previously considered to be a form of regeneration. Specifically, through-and-through ear punches rapidly attain full closure with normal tissue architecture reminiscent of regeneration seen in amphibians as opposed to scarring, as usually seen in mammals. Histologically, we have demonstrated normal cell growth and microanatomy, including angiogenesis and chondrogenesis, as opposed to control C57BL/6 mice which have ear holes that contract minimally but do not close. Finally, this phenomenon is a genetically definable quantitative trait.

Copyright 1998 Academic Press.

PMID:
9683548
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk