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Science. 1998 Jul 3;281(5373):60-3.

Going the distance: a current view of enhancer action.

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  • 1Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093-347, USA.


In eukaryotes, transcription of genes by RNA polymerase II yields messenger RNA intermediates from which protein products are synthesized. Transcriptional enhancers are discrete DNA elements that contain specific sequence motifs with which DNA-binding proteins interact and transmit molecular signals to genes. Here, current models regarding the role of enhancers in the regulation of transcription by RNA polymerase II are presented.

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