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Neurochem Int. 1998 May-Jun;32(5-6):421-5.

New insights into molecular structure and function of ectonucleotidases in the nervous system.

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  • 1AK Neurochemie, Biozentrum der J.W. Goethe-Universit├Ąt, Frankfurt am Main, Germany.


Nucleotides can be released as signaling substances in the nervous system from both neural and glial cells. Their function is terminated by ecto-nucleotidases and sequential extracellular metabolism to the nucleoside. Recently considerable progress has been made in unraveling the molecular structure of an ecto-ATPase and an ecto-ATP diphosphohydrolase, two closely related ectoenzymes. Molecular structure, tissue distribution and functional properties of the ecto-nucleotidases are discussed with particular emphasis on the nervous system.

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