The outcome of patients with hypogammaglobulinemia...[J Pediatr. 1998]

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1: J Pediatr. 1998 Jul;133(1):144-6. Links

The outcome of patients with hypogammaglobulinemia in infancy and early childhood.

Dalal I, Reid B, Nisbet-Brown E, Roifman CM.

Division of Immunology/Allergy, Hospital for Sick Children, Toronto, Ontario, Canada.

A 10-year prospective cohort study followed the evolution of antibodies in children less than 4 years of age with hypogammaglobulinemia. Three patterns were identified: in group 1, immunoglobulins and antibody production normalized;iin group 2, patients continued to have low IgG levels; and in group 3, IgG levels normalized but antibody levels were transient. Statistical analysis showed that invasive infection or low tetanus antibodies at presentation were associated with the development of significant humoral immunodeficiency.

PMID: 9672529 [PubMed - indexed for MEDLINE]

A prospective study on children with initial diagnosis of transient hypogammaglobulinemia of infancy: results from the Italian Primary Immunodeficiency Network. [Int J Immunopathol Pharmacol. 2008]
Symptomatic hypogammaglobulinemia in infancy and childhood - clinical outcome and in vitro immune responses. [BMC Fam Pract. 2004]
Transient hypogammaglobulinemia of infancy: clinical and immunologic features of 40 new cases. [Pediatr Int. 2000]
Infants presenting with recurrent infections and low immunoglobulins: characteristics and analysis of normalization. [J Clin Immunol. 2006]
Transient hypogammaglobulinemia of infancy and early childhood: outcome of 30 cases. [Turk J Pediatr. 2004]
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The outcome of patients with hypogammaglobulinemia in infancy and early childhood.

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