Endocrinol Metab Clin North Am. 1998 Jun;27(2):465-83.

The science and therapy of glucocorticoid-induced bone loss.

Source

Division of Rheumatology, University of California at San Francisco, USA.

Abstract

Glucocorticoids are critical in the management of chronic, noninfectious, inflammatory diseases. Bone loss is a most devastating side effect of these powerful medications. Glucocorticoids produce bone loss by altering calcium metabolism, suppressing gonadal hormone production, and inhibiting bone formation. Now that the mechanism of glucocorticoid-induced bone loss is understood and effective medications are available, this disease can be prevented and reversed.

PMID:: 9669150; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

MD Consult

Medical

Supplemental Content

Related citations

Review Secondary osteoporosis: underlying disease and the risk for glucocorticoid-induced osteoporosis. [Clin Ther. 2004]
Review Secondary osteoporosis: underlying disease and the risk for glucocorticoid-induced osteoporosis.
Boling EP. Clin Ther. 2004 Jan; 26(1):1-14.
Review Recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis: 2001 update. American College of Rheumatology Ad Hoc Committee on Glucocorticoid-Induced Osteoporosis. [Arthritis Rheum. 2001]
Review Recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis: 2001 update. American College of Rheumatology Ad Hoc Committee on Glucocorticoid-Induced Osteoporosis.
. Arthritis Rheum. 2001 Jul; 44(7):1496-503.
Review [Glucocorticoid-induced osteoporosis]. [Orv Hetil. 2000]
Review [Glucocorticoid-induced osteoporosis].
Tóth M, Tulassay Z. Orv Hetil. 2000 Jan 30; 141(5):219-23.
Review Glucocorticoid-induced osteoporosis: a review on pathophysiology and treatment options. [Minerva Med. 2008]
Review Glucocorticoid-induced osteoporosis: a review on pathophysiology and treatment options.
De Nijs RN. Minerva Med. 2008 Feb; 99(1):23-43.
Review Glucocorticoid-induced osteoporosis and its treatment. [Clin Orthop Relat Res. 2006]
Review Glucocorticoid-induced osteoporosis and its treatment.
Pennisi P, Trombetti A, Rizzoli R. Clin Orthop Relat Res. 2006 Feb; 443:39-47.

See reviews... See all...

Cited by 6 PubMed Central articles

Review Prevention and treatment of systemic glucocorticoid side effects. [Int J Dermatol. 2010]
Review Prevention and treatment of systemic glucocorticoid side effects.
Moghadam-Kia S, Werth VP. Int J Dermatol. 2010 Mar; 49(3):239-48.
Review Long-term therapy in COPD: any evidence of adverse effect on bone? [Int J Chron Obstruct Pulmon Dis. 2009]
Review Long-term therapy in COPD: any evidence of adverse effect on bone?
Langhammer A, Forsmo S, Syversen U. Int J Chron Obstruct Pulmon Dis. 2009; 4:365-80. Epub 2009 Oct 19.
Glucocorticoids suppress bone formation via the osteoclast. [J Clin Invest. 2006]
Glucocorticoids suppress bone formation via the osteoclast.
Kim HJ, Zhao H, Kitaura H, Bhattacharyya S, Brewer JA, Muglia LJ, Ross FP, Teitelbaum SL. J Clin Invest. 2006 Aug; 116(8):2152-60. Epub 2006 Jul 27.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The science and therapy of glucocorticoid-induced bone loss.
The science and therapy of glucocorticoid-induced bone loss.
Endocrinol Metab Clin North Am. 1998 Jun ;27(2):465-83.

PubMed
[The Charles Bonnet syndrome: visual hallucinations in the aged without mental d...
[The Charles Bonnet syndrome: visual hallucinations in the aged without mental deficiency].
Ann Med Psychol (Paris). 1967 Dec ;2(5):678-702.

PubMed
Human immunodeficiency virus and migrant labor in South Africa.
Human immunodeficiency virus and migrant labor in South Africa.
Int J Health Serv. 1991 ;21(1):157-73.

PubMed
Localized primary (AL) amyloid tumor of the breast. Cytologic, histologic, immun...
Localized primary (AL) amyloid tumor of the breast. Cytologic, histologic, immunocytochemical and ultrastructural observations.
Am J Surg Pathol. 1986 Aug ;10(8):539-45.

PubMed
'Lupus-prone' mice are susceptible to organ-specific autoimmune disease, experim...
'Lupus-prone' mice are susceptible to organ-specific autoimmune disease, experimental allergic encephalomyelitis.
Pathobiology. 1994 ;62(3):113-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: