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Curr Opin Struct Biol. 1998 Jun;8(3):294-300.

Structure and dynamics of ribosomal RNA.

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  • 1Department of Chemistry and Biochemistry, University of Maryland, College Park 20742-2021, USA.


Over the past two years, progress in X-ray crystallography, NMR spectroscopy and electron microscopy has begun to reveal the complex structure of the RNA within the ribosome. The structures of ribosomal proteins L11 and S15, among others, show how RNA-protein interactions organize the conformation of the junctions between ribosomal RNA helices. Genetic and biochemical methods have also identified a three base-pair switch within the 16S rRNA that is linked to mRNA decoding.

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