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Fertil Steril. 1998 Jul;70(1):94-101.

Pituitary desensitization to gonadotropin-releasing hormone increases abdominal adiposity in hyperandrogenic anovulatory women.

Author information

  • 1Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota, USA. DDUMESIC@MAYO.EDU

Abstract

OBJECTIVE:

To determine whether hyperandrogenism in anovulatory women affects body fat distribution.

DESIGN:

Prospective nonrandomized study.

SETTING:

An academic research environment.

PATIENT(S):

Ten hyperandrogenic anovulatory patients and 10 healthy women matched by body mass index.

INTERVENTION(S):

Regional body fat analysis was performed before and after 3 months of GnRH analogue (GnRH-a) therapy.

MAIN OUTCOME MEASURE(S):

Body fat distribution was measured by waist-to-hip circumference ratio, single-slice computed tomography imaging (L2-3 interspace), and total body dual-energy x-ray absorptiometry.

RESULT(S):

Weight, body mass index, waist-to-hip circumference ratio, total body and leg fat mass, and subcutaneous adipose area were unaffected by the presence of hyperandrogenism or the use of GnRH-a therapy. Basal abdominal fat mass, abdomen-to-leg fat mass ratio, visceral adipose area, and total visceral adipose volume were comparable in both study groups. The abdominal fat mass increased in both groups during GnRH-a therapy, whereas the abdomen-to-leg fat mass ratio rose significantly only in the hyperandrogenic patients. During GnRH-a therapy, the hyperandrogenic patients demonstrated a significant increase in visceral adipose area compared with the healthy women so that total visceral adipose volume increased significantly in the former but not the latter.

CONCLUSION(S):

Three months of GnRH-a administration preferentially increased abdominal fat, as measured by single-slice computed tomography imaging and total body dual-energy x-ray absorptiometry, in hyperandrogenic anovulatory women.

PMID:
9660428
[PubMed - indexed for MEDLINE]
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