Immunity. 1998 Jun;8(6):667-73.

Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen.

Gütgemann I, Fahrer AM, Altman JD, Davis MM, Chien YH.

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Department of Microbiology and Immunology, Stanford University, California 94305, USA.

Abstract

To understand how orally introduced antigen regulates peripheral immune responses, we fed cytochrome c protein to mice transgenic for the beta chain of a cytochrome c-specific TCR and followed the antigen-specific T cell responses with a cyt c/I-Ek tetramer staining reagent. We find that within 6 hr of cytochrome c administration, antigen-specific systemic T cell activation is induced, and spleen cells gain the ability to stimulate cytochrome c-specific T cell responses. Feeding multiple low doses of cytochrome c down-regulates the systemic immune response, which can be correlated with a reduction of antigen-specific T cells and not with immune deviation. These results suggest that systemic distribution of antigen contributes significantly to oral tolerance induction.

PMID:: 9655480; [PubMed - indexed for MEDLINE]

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