Science. 1978 Aug 11;201(4355):534-5.

Choice behavior in rhesus monkeys: cocaine versus food.

Abstract

Rhesus monkeys were allowed to choose between intravenous injections of cocaine and food reinforcement for lever pressing. A choice trial was available every 15 minutes continuously for 8 days. The animals chose cocaine almost exclusively, which resulted in high cocaine intake, decreased food intake, weight loss, and marked behavioral toxicity. The study provides evidence of the reinforcing efficacy of cocaine.

PMID:: 96531; [PubMed - indexed for MEDLINE]

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Research Support, U.S. Gov't, Non-P.H.S.

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Cocaine

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The effects of electric shock on responding maintained by cocaine injections in a choice procedure in the rhesus monkey. [Psychopharmacology (Berl). 1977]
The effects of electric shock on responding maintained by cocaine injections in a choice procedure in the rhesus monkey.
Johanson CE. Psychopharmacology (Berl). 1977 Aug 16; 53(3):277-82.
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Johanson CE, Schuster CR. J Pharmacol Exp Ther. 1975 May; 193(2):676-88.
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Effects of delay to reinforcement on the choice between cocaine and food in rhesus monkeys.
Woolverton WL, Anderson KG. Psychopharmacology (Berl). 2006 May; 186(1):99-106. Epub 2006 Mar 28.

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Cited by 11 PubMed Central articles

Exploring the limits and utility of operant conditioning in the treatment of drug addiction. [Behav Anal. 2004]
Exploring the limits and utility of operant conditioning in the treatment of drug addiction.
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Cocaine is low on the value ladder of rats: possible evidence for resilience to addiction. [PLoS One. 2010]
Cocaine is low on the value ladder of rats: possible evidence for resilience to addiction.
Cantin L, Lenoir M, Augier E, Vanhille N, Dubreucq S, Serre F, Vouillac C, Ahmed SH. PLoS One. 2010 Jul 28; 5(7):e11592. Epub 2010 Jul 28.
Effects of extended cocaine access and cocaine withdrawal on choice between cocaine and food in rhesus monkeys. [Neuropsychopharmacology. 2010]
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