Transcriptional control: Tat cofactors and transcr...[Curr Biol. 1998]

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1: Curr Biol. 1998 Jun 18;8(13):R447-9. Links

Transcriptional control: Tat cofactors and transcriptional elongation.

Yankulov K, Bentley D.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

HIV-1 gene expression requires the transactivator Tat, which stimulates viral transcript elongation. Recent results show that two cellular cyclin-dependent kinases, which phosphorylate the carboxy-terminal domain of the RNA polymerase II large subunit, contact Tat and contribute to the control of transcriptional elongation.

PMID: 9651670 [PubMed - indexed for MEDLINE]

The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1, and Tat.
J Virol. 1998 Sep; 72(9):7154-9.

[J Virol. 1998]
ReviewHIV-1 Tat: coping with negative elongation factors.
Curr Opin Immunol. 1999 Aug; 11(4):460-5.

[Curr Opin Immunol. 1999]
HIV-1 Tat-associated RNA polymerase C-terminal domain kinase, CDK2, phosphorylates CDK7 and stimulates Tat-mediated transcription.
Biochem J. 2002 Jun 15; 364(Pt 3):649-57.

[Biochem J. 2002]
ReviewTat, Tat-associated kinase, and transcription.
J Biomed Sci. 1998; 5(1):24-7.

[J Biomed Sci. 1998]
Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription.
Mol Cell Biol. 2000 Jul; 20(14):5077-86.

[Mol Cell Biol. 2000]
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Cited by 6 PubMed Central articles

Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription.
Zhou M, Deng L, Lacoste V, Park HU, Pumfery A, Kashanchi F, Brady JN, Kumar A. J Virol. 2004 Dec; 78(24):13522-33.

[J Virol. 2004]
The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA.
Zhou M, Deng L, Kashanchi F, Brady JN, Shatkin AJ, Kumar A. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12666-71. Epub 2003 Oct 20.

[Proc Natl Acad Sci U S A. 2003]
Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription.
Zhou M, Halanski MA, Radonovich MF, Kashanchi F, Peng J, Price DH, Brady JN. Mol Cell Biol. 2000 Jul; 20(14):5077-86.

[Mol Cell Biol. 2000]
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