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    Curr Biol. 1998 Jun 18;8(13):R447-9.

    Transcriptional control: Tat cofactors and transcriptional elongation.

    Yankulov K, Bentley D.

    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

    HIV-1 gene expression requires the transactivator Tat, which stimulates viral transcript elongation. Recent results show that two cellular cyclin-dependent kinases, which phosphorylate the carboxy-terminal domain of the RNA polymerase II large subunit, contact Tat and contribute to the control of transcriptional elongation.

    PMID: 9651670 [PubMed - indexed for MEDLINE]

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