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J Clin Microbiol. 1998 Jul;36(7):2073-5.

Assessment of spontaneous fluctuations of viral load in untreated patients with chronic hepatitis C by two standardized quantitation methods: branched DNA and Amplicor Monitor.

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  • 1Alphabio Laboratory, Department of Biochemistry, Hôpital de la Conception, Marseille, France. alphabio@wanadoo.fr

Abstract

Quantitation of hepatitis C virus (HCV) RNA in serum has been used to predict and monitor the efficacy of interferon therapy in chronic HCV infection. We prospectively studied the fluctuation of viremia by a longitudinal follow-up of HCV RNA levels for 2 months in six untreated patients. Spontaneous fluctuations of HCV RNA ranged from 2.8- to 5.7-fold with branched DNA assay and from 2.9- to 5.6-fold with Monitor. These large spontaneous fluctuations (up to 0.75 log), observed daily, weekly, and monthly, raise doubt about the clinical value of a single assessment of pretherapeutic viremia.

PMID:
9650965
[PubMed - indexed for MEDLINE]
PMCID:
PMC104981
Free PMC Article

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