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Scand J Gastroenterol. 1998 May;33(5):523-8.

Antineutrophil and pancreatic autoantibodies in first-degree relatives of patients with inflammatory bowel disease.

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  • 1Medical Clinic, Klinikum Innenstadt, Ludwig-Maximilians Universit├Ąt, Munich, Germany.

Abstract

BACKGROUND:

Perinuclear antineutrophil antibodies (P-ANCA) are found in ulcerative colitis, and autoantibodies against exocrine pancreas (PAB) in Crohn's disease. Their potential role as genetic or pathophysiologic factors is unclear.

METHODS:

In 61 patients with ulcerative colitis, 76 patients with Crohn's disease, 101 first-degree relatives of patients with ulcerative colitis, 105 first-degree relatives of Crohn's disease patients, and 56 healthy unrelated controls autoantibodies were detected by indirect immunofluorescence.

RESULTS:

Forty-six per cent of patients with ulcerative colitis (28 of 61) and 38% of patients with Crohn's disease (29 of 76) were P-ANCA- and PAB-positive, respectively. In relatives of patients with ulcerative colitis P-ANCA were found in 3% (3 of 101), and in relatives of Crohn's disease patients PAB were detected in 4% (4 of 105), which is not significantly different from the occurrence in the healthy controls.

CONCLUSIONS:

The frequency of P-ANCA and PAB does not suggest a role as genetic markers for inflammatory bowel disease.

PMID:
9648993
[PubMed - indexed for MEDLINE]
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