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Int J Dermatol. 1998 Jun;37(6):461-4.

A pilot study on bacterial viability in acne. Assessment using dual flow cytometry on microbials present in follicular casts and comedones.

Author information

  • 1Department of Dermatopathology, University of Liège, Belgium.

Abstract

BACKGROUND:

Antibiotic therapy is one of the main methods of acne treatment, however, bacterial resistance is on the rise and can affect the treatment outcome. Quantitative bacteriologic cultures are the gold standard methodology for the assessment of such a problem; however, certain important biological aspects remain uncovered.

OBJECTIVE:

The purpose of this study was to compare the antibacterial activity of minocycline and lymecycline in sebaceous follicle infundibula and comedones of acne patients.

METHOD:

We used a recently introduced flow cytometric method, allowing a distinction to be made between viable, injured (presumably resistant), and dead microorganisms.

RESULTS:

Minocycline (100 mg) proved to be superior to lymecycline (600 mg) in abating the microflora harboring in the sebaceous follicles of acne patients.

CONCLUSIONS:

The dissimilar bioavailability and antimicrobial efficacy between the two bacteriostatic agents may impart different clinical efficacy.

PMID:
9646139
[PubMed - indexed for MEDLINE]
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