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    FEBS Lett. 1998 May 22;428(1-2):80-4.

    N-copine: a novel two C2-domain-containing protein with neuronal activity-regulated expression.

    Nakayama T, Yaoi T, Yasui M, Kuwajima G.

    Source

    CNS Research Laboratories, Shionogi and Co., Ltd., Osaka, Japan.

    Abstract

    Neuronal activity is often associated with changes in gene expression. By a two-dimensional cDNA-display system, restriction landmark cDNA scanning, we identified a novel gene whose expression in the hippocampus was up-regulated by kainate stimulation. The mRNA expression was detected only in brain and up-regulated by the stimulation evoking CA3-CA1 long-term potentiation. The encoded protein contains two copies of C2-domain, known as the Ca2+-binding domain of PKC-gamma, and shows 49% identity with human copine I. We designated this protein N-copine (neuronal-copine). N-copine may have a role in synaptic plasticity.

    PMID:
    9645480
    [PubMed - indexed for MEDLINE]

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