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Curr Opin Cell Biol. 1998 Jun;10(3):366-72.

TCF: transcriptional activator or repressor?

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  • MRC Laboratory of Molecular Biology, Cambridge, UK. mb2@mrc-lmb.cam.ac.uk


T cell factor, or TCF, has been identified as the transcriptional response factor activated by Wnt-1 and Wingless signalling. TCF is thought to be a potent architectural factor which facilitates assembly of multiprotein enhancer complexes. Its deregulation in the colonic epithelium, and in other cells, leads to cancer. This raises the question of how TCF is kept inactive in unstimulated cells.

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