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Nature. 1998 Jun 11;393(6685):537-44.

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.

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  • 1Sanger Centre, Wellcome Trust Genome Campus, Hinxton, UK. stcole@pasteur.fr

Erratum in

  • Nature 1998 Nov 12;396(6707):190.

Abstract

Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of its coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation.

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PMID:
9634230
[PubMed - indexed for MEDLINE]
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