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Science. 1998 Jun 19;280(5371):1880-4.

HIV-1 regulatory/accessory genes: keys to unraveling viral and host cell biology.

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  • 1Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North-Mailstop C2-023, Seattle, Washington 98109-1024, USA. memerman@fhcrc.org.


Human immunodeficiency virus type-1 (HIV-1) manipulates fundamental host cell processes in sophisticated ways to achieve optimum replicative efficiency. Recent studies have provided new details on the molecular interactions of HIV-1 with its host cell. For example, HIV-1 encodes a protein that regulates transcriptional elongation by interacting with a cellular cyclin-dependent kinase, another that activates the specific nuclear export of viral RNA, and several others that affect the intracellular trafficking of viral and host cell proteins. Detailed analysis of the interplay between these viral proteins and normal cellular activities has provided new insights into central questions of virology and host cell biology.

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