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Curr Opin Struct Biol. 1998 Apr;8(2):150-8.

Filamentous phage structure, infection and assembly.

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  • 1Cambridge Centre for Molecular Recognition, Department of Biochemistry, University of Cambridge, UK.


The structural model of filamentous phage derived by X-ray fibre diffraction is supported by spectroscopic and genetic experiments. The structure of the receptor-binding domain at the end of the phage and the structure of the phage-coded intracellular DNA-binding protein have been determined at high resolution. The recent dissection of the virus life cycle by genetic and biochemical analyses, combined with structural information, suggests models for virus infection and assembly.

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