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J Antibiot (Tokyo). 1998 Apr;51(4):418-22.

Isolation and structure of an antimitotic cyclic peptide, ustiloxin F: chemical interrelation with a homologous peptide, ustiloxin B.

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  • 1Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.

Abstract

Ustiloxin F, a microtubule inhibitor, was isolated as a minor metabolite of Ustilaginoidea virens. The structure was determined from the spectral data and by chemical interrelation to ustiloxin B through reductive removal of the sulfoxide-containing side chain of ustiloxin B to give ustiloxin F. Ustiloxin F inhibited microtubule assembly with an IC50 value of 10.3 microM.

PMID:
9630863
[PubMed - indexed for MEDLINE]
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