Send to

Choose Destination
See comment in PubMed Commons below
Clin Chem. 1998 Jun;44(6 Pt 1):1251-5.

Determination of ciprofloxacin in plasma and urine by HPLC with ultraviolet detection.

Author information

  • 1Department of Clinical Pharmacology and Therapeutics, Oita Medical University, Japan.


A simple, sensitive isocratic method for the detection and quantification of ciprofloxacin in plasma and urine has been developed. The assay consisted of reversed-phase HPLC with ultraviolet detection. Plasma proteins were removed by a fast and efficient procedure. For the urine samples, the only required sample preparation was dilution. Separation was achieved on a C18 reversed-phase column. The quantification limit was 0.01 mg/L in plasma and 0.5 mg/L in urine. This method was sufficiently sensitive for pharmacokinetic studies.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk