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Clin Chem. 1998 Jun;44(6 Pt 1):1251-5.

Determination of ciprofloxacin in plasma and urine by HPLC with ultraviolet detection.

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  • 1Department of Clinical Pharmacology and Therapeutics, Oita Medical University, Japan.

Abstract

A simple, sensitive isocratic method for the detection and quantification of ciprofloxacin in plasma and urine has been developed. The assay consisted of reversed-phase HPLC with ultraviolet detection. Plasma proteins were removed by a fast and efficient procedure. For the urine samples, the only required sample preparation was dilution. Separation was achieved on a C18 reversed-phase column. The quantification limit was 0.01 mg/L in plasma and 0.5 mg/L in urine. This method was sufficiently sensitive for pharmacokinetic studies.

PMID:
9625049
[PubMed - indexed for MEDLINE]
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