Your browser version may not work well with NCBI's Web applications. More information here...
1: Antimicrob Agents Chemother. 1998 Jun;42(6):1488-92.Click here to read Click here to read Links

Efficacies of zinc-finger-active drugs against Giardia lamblia.

Nash T, Rice WG.

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. tnash@atals.niaid.nih.gov

Twenty-nine of 34 (85%) Zn-finger-active compounds at 300 microM or less inhibited the growth of Giardia lamblia. The most active compound, disulfiram (Antabuse), was cidal at 1.23 +/- 0.32 microM. In the adult mouse model, significant in vivo activity was demonstrated by increased cure rates and decreased parasite burdens.

PMID: 9624499 [PubMed - indexed for MEDLINE]

PMCID: PMC105627

Patient Drug Information

  • Disulfiram (Antabuse® )

    Disulfiram is used to treat chronic alcoholism. It causes unpleasant effects when even small amounts of alcohol are consumed. These effects include flushing of the face, headache, nausea, vomiting, chest pain, weakness, ...

  • Source: AHFS Consumer Medication Information