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Am J Psychiatry. 1998 Jun;155(6):774-8.

Decreased caudate volume in neuroleptic-naive psychotic patients.

Author information

  • 1Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213-2593, USA. Keshavan+@Pitt.edu

Abstract

OBJECTIVE:

Previous studies, mostly involving neuroleptic-treated patients, have suggested enlarged basal ganglia size in schizophrenia. The authors sought to examine basal ganglia volume in neuroleptic-naive psychotic patients.

METHOD:

Magnetic resonance imaging volumetric studies were conducted in newly diagnosed neuroleptic-naive schizophrenic and non-schizophrenic psychotic patients and in matched healthy comparison subjects.

RESULTS:

Both patient groups had bilaterally reduced caudate, but not putamen, volumes, compared to the healthy subjects, after adjustment for intracranial volume.

CONCLUSIONS:

Decreases in caudate volume in newly diagnosed psychotic patients may be related to the primary pathophysiology of these disorders; prior observations of increased caudate volume may reflect effects of neuroleptic treatment.

PMID:
9619149
[PubMed - indexed for MEDLINE]
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