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Depress Anxiety. 1998;7(2):89-91.

Psychostimulant augmentation of second generation antidepressants: a case series.

Author information

  • 1Department of Psychiatry, SUNY Health Science Center at Syracuse 13210, USA.

Abstract

OBJECTIVE:

The authors attempted to treat Major Depressive Disorder (MDD) suboptimally responsive to one of the newer (second-generation) antidepressants by augmentation with a psychostimulant medication.

METHOD:

Seven cases of MDD showing a partial response to an adequate trial of a second generation antidepressant were augmented with a psychostimulant.

RESULTS:

A marked improvement in clinical symptoms of depression was noted in all cases, with particular improvement in apathy and feelings of fatigue.

CONCLUSION:

Psychostimulant augmentation of the newer generation antidepressants is a promising new strategy. Further controlled investigation is warranted to explore various aspect of this method.

PMID:
9614599
[PubMed - indexed for MEDLINE]
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