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JAMA. 1998 May 27;279(20):1629-32.

Nebulized budesonide and oral dexamethasone for treatment of croup: a randomized controlled trial.

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  • 1Department of Pediatrics, University of Ottawa, Ontario, Canada. terry.klassen@sympatico.ca

Abstract

CONTEXT:

The effectiveness of glucocorticoids for patients with croup is well established but it remains uncertain which glucocorticoid regimen is most effective.

OBJECTIVE:

To determine the effectiveness of 3 glucocorticoid regimens in patients with croup.

DESIGN:

Randomized controlled trial with parallel design.

SETTING:

Emergency departments of 2 Canadian pediatric tertiary care hospitals.

PARTICIPANTS:

Children with a clinical syndrome consistent with croup, aged 3 months to 5 years, with a croup score of 2 or greater following at least 15 minutes of mist therapy.

INTERVENTIONS:

Oral dexamethasone, 0.6 mg/kg, and nebulized placebo; oral placebo and nebulized budesonide, 2 mg; or oral dexamethasone, 0.6 mg/kg, and nebulized budesonide, 2 mg.

MAIN OUTCOME MEASURES:

Westley croup score (primary outcome), hospital admission rates, time spent in the emergency department, return visits to the emergency department, or ongoing symptoms at 1 week.

RESULTS:

The mean change in the croup score from baseline to the final study assessment was -2.3 (95% confidence interval [CI], -2.6 to -2.0) in the budesonide group (n = 65), -2.4 (95% CI, -2.6 to -2.2) in the dexamethasone group (n = 69), and -2.4 (95% CI, -2.7 to -2.1) in the budesonide and dexamethasone group (n = 64, P = .70).

CONCLUSIONS:

Based on the similar outcomes in the 3 groups, oral dexamethasone is the preferred intervention because of its ease of administration, lower cost, and more widespread availability.

PMID:
9613912
[PubMed - indexed for MEDLINE]
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