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Rheum Dis Clin North Am. 1998 May;24(2):237-59.

Rheumatic fever. The relationships between host, microbe, and genetics.

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  • 1Hospital for Special Surgery, Cornell University Medical College, New York, New York, USA.


Acute rheumatic fever is a delayed, nonsuppurative sequela of a pharyngeal infection with the group A streptococcus. The onset of the disease is usually characterized by an acute febrile illness; however, there may be chronic involvement of the heart and/or central nervous system. The article explores the relationship between the initial infection and host-microbial interactions that may be operative in disease pathogenesis.

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