Format

Send to:

Choose Destination
See comment in PubMed Commons below
Ann Pharmacother. 1998 May;32(5):564-73.

Treatment and prophylaxis of disseminated Mycobacterium avium complex in HIV-infected individuals.

Author information

  • 1Clinical Research Scientist, Respiratory Clinical Research, Glaxo Wellcome, Inc., Research Triangle Park, NC, USA.

Abstract

OBJECTIVE:

To review the pathophysiology, epidemiology, treatment, and prophylaxis of disseminated Mycobacterium avium complex (MAC) infection in HIV-infected individuals.

DATA SOURCES:

A MEDLINE (January 1966-July 1997) and AIDSLINE (January 1980-July 1997) search of basic science articles pertinent to the MAC infection in HIV-infected patients.

STUDY SELECTION AND DATA EXTRACTION:

All articles were considered for possible inclusion in the review. Pertinent information, as judged by the authors, was selected for discussion.

DATA SYNTHESIS:

The organism, epidemiology, and pathophysiology of disseminated MAC are discussed for background. A review of clinical trials for the treatment and prophylaxis of disseminated MAC are presented, along with unresolved issues concerning these topics.

CONCLUSIONS:

The incidence of disseminated MAC has increased dramatically with the AIDS epidemic. The infection can lead to increased morbidity and mortality in HIV-infected patients. Treatment regimens for patients with a positive culture for MAC from a sterile site should include two or more drugs, including clarithromycin. Prophylaxis against disseminated MAC should be considered for patients with a CD4 cell count of less than 50/mm3.

PMID:
9606478
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk