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Infect Immun. 1998 Jun;66(6):3003-5.

Secreted aspartyl proteinases and interactions of Candida albicans with human endothelial cells.

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  • 1Division of Infectious Diseases, St. John's Cardiovascular Research Center, Department of Medicine, Harbor-UCLA Research and Education Institute, Torrance, California 90509, USA. Ibrahim@AFP76.HUMC.EDU

Abstract

The endothelial cell interactions of homozygous null mutants of Candida albicans that were deficient in secreted aspartyl proteinase 1 (Sap1), Sap2, or Sap3 were investigated. Only Sap2 was found to contribute to the ability of C. albicans to damage endothelial cells and stimulate them to express E-selectin. None of the Saps studied appears to play a role in C. albicans adherence to endothelial cells.

PMID:
9596782
PMCID:
PMC108304
[PubMed - indexed for MEDLINE]
Free PMC Article
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