Format

Send to:

Choose Destination
See comment in PubMed Commons below
Blood. 1998 Jun 1;91(11):4152-7.

Antibodies to protease-activated receptor 3 inhibit activation of mouse platelets by thrombin.

Author information

  • 1Cardiovascular Research Institute, Daiichi Research Center, University of California, San Francisco, San Francisco, CA 94143-0130, USA.

Abstract

Recent studies of mice deficient in the thrombin receptor, protease-activated receptor 1 (PAR1), provided definitive evidence for the existence of a second thrombin receptor in mouse platelets. We recently identified a new thrombin receptor designated protease-activated receptor 3 (PAR3). The mRNA encoding a mouse homologue of PAR3 was highly expressed in mouse splenic megakaryocytes, making it a good candidate for the missing mouse platelet thrombin receptor. We now report that PAR3 protein is expressed on the surface of mouse platelets and that PAR3 antibodies partially inhibit activation of mouse platelets by thrombin but not U46619, a thromboxane receptor agonist. These observations suggest that PAR3 contributes to mouse platelet activation by thrombin.

PMID:
9596661
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk