Display Settings:

Format

Send to:

Choose Destination
Trends Genet. 1998 Apr;14(4):151-5.

The riddle of MAP kinase signaling specificity.

Author information

  • 1Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. madhani@wi.mit.edu

Abstract

Cells encounter an enormous variety of signals in their environments and must respond to each stimulus appropriately with changes in their genetic programs. Many of these external signals are transduced by a highly conserved eukaryotic signaling mechanism, the mitogen-activated protein kinase (MAPK) cascade. How are the myriad of inputs transduced accurately so that each evokes a specific response? One mechanism would be to have a distinct MAPK cascade for each signal; however, the situation appears to be more complicated.

PMID:
9594663
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk