Display Settings:

Format

Send to:

Choose Destination
Trends Microbiol. 1998 Apr;6(4):154-9.

Antibacterial and anti-inflammatory agents that target endotoxin.

Author information

  • 1Dept of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.

Abstract

Antibiotic-resistant bacterial infections are a major clinical problem. Lipid A, the active part of lipopolysaccharide endotoxins in Gram-negative bacteria, is an intriguing target for new antibacterial and anti-inflammatory agents. Inhibition of lipid A biosynthesis kills most Gram-negative bacteria, increases bacterial permeability to antibiotics and decreases endotoxin production.

PMID:
9587193
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk