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Int J Radiat Biol. 1998 Apr;73(4):373-6.

The multi-step nature of carcinogenesis and the implications for risk analysis.

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  • 1National Radiological Protection Board, Chilton, Didcot, Oxon, UK.

Abstract

PURPOSE:

For the purposes of constructing biologically realistic models of radiation cancer risk it is necessary to have detailed knowledge of the post-irradiation mechanisms involved.

METHODS:

This brief review considers selected aspects of DNA damage response, tumour initiation/development, together with attendant factors and provides comment on the implications for cancer risk estimation and some of the uncertainties that remain.

CONCLUSIONS:

It is judged from studies with animal models that, in the main, radiation tumorigenesis proceeds in a conventional multi-step fashion following radiation-induced specific gene losses from single-target stem cells.

PMID:
9587074
[PubMed - indexed for MEDLINE]
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