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Nucleic Acids Symp Ser. 1997;(37):283-4.

In vitro selection of aptamers that bind to ribosome-inactivating toxins.

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  • 1Yokoyama CytoLogic Project, ERATO, Saitama, Japan.


Ribosome-inactivating proteins, such as ricin, pepocin and gypsophilin, catalyze the hydrolysis of a single N-glycosidic bond at a specific position in rRNAs. Aptamers targeting pepocin were selected from a random sequence RNA pool that spanned 30 positions. After 8 rounds, the anti-pepocin aptamers were sequenced and a conserved hairpin motif was identified. Interestingly, the selected motif is quite different from the toxin-binding domains of rRNAs.

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