Serotonin and vasoconstrictor synergism

Life Sci. 1998;62(19):1723-32. doi: 10.1016/s0024-3205(97)01166-1.

Abstract

Contractile synergism between serotonin (5-hydroxytryptamine, 5-HT) and other vasoconstrictor substances has been observed in a number of peripheral and cerebrovascular blood vessels. This phenomenon may play an important role in certain pathological states such as hypertension, peripheral vascular disease, and coronary spasm. In the present review, we summarize studies on the synergism between serotonin and other vasoconstrictor agents and focus on a recently described type of vasoconstrictor synergism in which precontraction with a non-5-HT receptor agonist yields an enhanced contractile response to serotonin which is mediated by previously inactive or "silent" 5-HT receptor subtypes.

Publication types

  • Review

MeSH terms

  • Animals
  • Arteries / drug effects*
  • Arteries / physiology
  • Drug Synergism
  • Humans
  • Hypertension / physiopathology
  • Muscle, Smooth, Vascular / drug effects*
  • Receptors, Serotonin / drug effects*
  • Receptors, Serotonin / metabolism
  • Serotonin / pharmacology*
  • Vasoconstriction / drug effects*
  • Vasoconstrictor Agents / pharmacology*

Substances

  • Receptors, Serotonin
  • Vasoconstrictor Agents
  • Serotonin