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Trends Biochem Sci. 1998 Apr;23(4):121-4.

Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: implications for intercellular signaling.

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  • 1Dept of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.


Receptor-like protein tyrosine phosphatase beta (RPTP beta) shows structural and functional similarity to cell adhesion molecules (CAMs). It binds to several neuronal CAMs and extracellular matrix (ECM) proteins that combine to form cell-recognition complexes. Here, the authors discuss the implications of such complexes for intercellular signaling, and the regulation of RPTP activity by cell-cell and cell-ECM contact.

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